Organo-Metalloid Compounds
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Filtered Search Results
Medchemexpress LLC FL118-C3-O-C-amide-C-NH2-d5 formate | 587.59 | 1 MG
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FL118-C3-O-C-amide-C-NH2-d5 formate is a deuterium labeled FL118-C3-O-C-amide-C-NH2 formate. This ADC linker is used in the synthesis of antibody-drug conjugates (ADCs).
- Deuterium labeled compound
- Used as an ADC linker
- Incorporates stable heavy isotopes as tracers
- Potential to affect pharmacokinetic and metabolic profiles of drugs
- For research use only
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eMolecules EMOLECULES INC
5000489661 3-BROMO-1 1 1-TRIFLUOROAC 100G
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Medchemexpress LLC Br-PEG3-MS | 2702323-73-5 | >95.0% | 291.16 | 50 MG
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Br-PEG3-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
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Medchemexpress LLC Abemaciclib (methanesulfonate) | 1231930-82-7 | 99.8% | 602.70 | 200 MG
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This compound is a selective and BBB-permeable inhibitor of CDK4/6, with half-maximal inhibitory concentrations (IC50s) of 2 nM and 10 nM for CDK4 and CDK6, respectively.
- Selective inhibition of key enzymes involved in cell cycle regulation.
- Permeates the blood-brain barrier.
- Reduces cell viability in various human cell lines, including HCT-116, MCF7, and PANC-1.
- Inhibits Rb phosphorylation, leading to a G1 arrest and suppressed proliferation.
- Activity is specific for cells that are proficient in Rb.
- Effective in reducing cell viability across multiple cancer cell lines.
- Demonstrates antiproliferative activity against human HCT116 and MCF7 cells.
- Shows inhibition in resistant cell lines.
- Causes a cooperative antitumor effect when combined with other agents in xenograft models.
- Leads to significant tumor growth inhibition in xenograft models.
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Medchemexpress LLC BCN-exo-PEG3-NH2 | 1841134-72-2 | >95.0% | C19H32N2O5 | 10MG
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BCN-exo-PEG3-NH2 is a BCN-functionalized PEG3 amine linker used in bioorthogonal conjugation and PROTAC linker synthesis. It provides a strained alkyne handle and a terminal primary amine to enable modular coupling strategies, and is commonly supplied in research-scale quantities at high reported purity.
- Provides a strained alkyne (BCN) for rapid bioorthogonal click reactions.
- Contains a PEG3 spacer for flexibility and improved solubility.
- Features a terminal primary amine for amide or reductive amination conjugation.
- Suitable for linker construction in targeted degradation and bioconjugation workflows.
- Supplied in research-scale quantities with supplier-reported high purity.
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000737873 LINALYL ISOBUTYRATE 50MG
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eMolecules 3-BROMO-1 1 1-TRIFLUOROACE 10G
5000189140 3-BROMO-1 1 1-TRIFLUOROACE 10G
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eMolecules EMOLECULES INC
5000191409 TERT-BUTYL-2-IODOETHOXY 100MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000744500 TCO-PEG3-ACID 10MG
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Medchemexpress LLC Aminooxy-PEG3-acid | 1807540-79-9 | 95.0% | 237.25 | 100 MG
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Aminooxy-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000744743 N-AZIDO-PEG3-N-BOC 500MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000697674 ABEMACICLIB METHANE 5MG
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000734957 PEG3-BISCHLORO 5G
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Sigma Aldrich Fine Chemicals Biosciences Ethyl isobutyrate 98 fCC f
Ethyl isobutyrate is a potent odorant in oranges grapefruit and Greek virgin olive oils.
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Medchemexpress LLC AK-778-XXMU | 1227045-76-2 | 99.9% | C22H17ClN2O3 | 25 MG
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AK-778-XXMU is a potent DNA binding inhibitor 2 (ID2) antagonist with a KD of 129 nM. It inhibits the ID2-KDR signaling axis, leading to the down-regulation of downstream angiogenic factors (VEGFA) and invasion-related proteins (MMP2/9), while up-regulating the tumor suppressor factor (PTEN). It can inhibit cell migration and invasion of glioma cell lines, induce apoptosis, and demonstrates significant cancer-suppressing potency. This compound is used for the study of glioma.
- Potent DNA binding inhibitor 2 (ID2) antagonist
- Inhibits cell migration and invasion of glioma cell lines
- Induces apoptosis
- Demonstrates significant cancer-suppressing potency
- Inhibits ID2-KDR signaling axis
- Down-regulates angiogenic factors (VEGFA) and invasion-related proteins (MMP2/9)
- Up-regulates tumor suppressor factor (PTEN)
- Suitable for the study of glioma
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